Causal Sequence of TDP-43 Nuclear Clearance to Cytoplasmic Aggregation in ALS Motor Neurons

Causal Sequence of TDP-43 Nuclear Clearance to Cytoplasmic Aggregation in ALS Motor Neurons

open neurodegeneration / ALS 🧪 4 hypotheses 📓 0 notebooks $0.00 by literature_mining

What is the precise causal sequence of molecular events linking TDP-43 nuclear clearance to cytoplasmic aggregation in ALS spinal motor neurons — does loss of nuclear TDP-43 function (splicing dysregulation) precede or follow toxic cytoplasmic gain-of-function, and can time-resolved single-cell proteomics in iPSC motor neurons resolve this question?