🔬 Analysis Details
Biophysical Determinants Shifting FUS/TDP-43 Phase Separation to Pathological Aggregates
open
neurodegeneration / ALS
🧪 4 hypotheses
📓 0 notebooks
$0.00
by literature_mining
What are the biophysical determinants — RNA binding stoichiometry, post-translational modifications, crowding agents — that shift FUS and TDP-43 from functional liquid-liquid phase-separated condensates to irreversible amyloid-like aggregates, and can in-cell cryo-electron tomography resolve the structural transitions in patient-derived iPSC motor neurons?