BACKGROUND: Spaceflight exposes living organisms to mechanical unloading and cosmic radiation that profoundly reshape metabolism and tissue function. Because mitochondria play a crucial role in dealing with stress responses, members of the SLC25A carrier family become crucial checkpoints for controlling cellular energy and redox homeostasis. METHODS: In this study, we examined the expression of 53 SLC25A genes across osteocytes, human bone marrow-derived mesenchymal stem cells (hBMSCs), and mous...