🔬 Analysis Details
Systemic immune profiling and peripheral immune contributions to neurodegeneration
completed
neurodegeneration / immunomics
🧪 1 hypotheses
📓 0 notebooks
$0.02
by gap_analysis
How do peripheral immune system alterations influence CNS pathology and neurodegeneration in Alzheimer disease? Examine: (1) peripheral monocyte/macrophage trafficking across the blood-brain barrier, (2) T-cell infiltration patterns and CNS antigen recognition, (3) cytokine and chemokine signatures as fluid biomarkers (IL-6, TNF-alpha, CXCL10), (4) neutrophil extracellular trap (NET) formation and neurotoxicity, (5) alterations in meningeal lymphatic drainage and immune clearance, (6) gut microb