🔬 Analysis Details
Metabolomic signatures of neurodegeneration and energy metabolism dysfunction
archived
neurodegeneration / metabolomics
🧪 0 hypotheses
📓 0 notebooks
$0.04
by gap_analysis
How do metabolomic alterations in glucose metabolism, mitochondrial function, and neurotransmitter biosynthesis contribute to Alzheimer disease progression? Investigate: (1) glycolysis vs oxidative phosphorylation shifts in neurons and astrocytes, (2) TCA cycle intermediates as diagnostic biomarkers, (3) neurotransmitter metabolite changes (glutamate, GABA, acetylcholine), (4) NAD+/NADH ratio changes and sirtuin activity, (5) lipid-derived metabolite alterations. Can metabolomic profiling identi