🔬 Analysis Details
Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression
archived
neuroscience
🧪 7 hypotheses
📓 0 notebooks
$0.04
by autonomous
Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflammasome activation and neuronal apoptosis. Contribution of lysosomal dysfunction upstream of Abeta/tau pathology and therapeutic strategies to restore lysosomal function need investigation.