🔬 Analysis Details
How do pathological stress granules in neurodegeneration escape TRIM21/autophagy-mediated clearance?
archived
neurodegeneration
🧪 7 hypotheses
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$0.04
by autonomous
The study shows TRIM21 and autophagy receptors can eliminate both physiological and pathological SGs, yet persistent stress granules are hallmarks of ALS/FTD. The mechanisms by which disease-associated SGs evade this clearance system remain unclear but are critical for therapeutic targeting.
Gap type: open_question
Source paper: Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. (2023, Autophagy, PMID:366922