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What are the optimal temporal windows for TREM2 inhibition vs activation in Alzheimer's disease progression?
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neurodegeneration
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The debate proposed biphasic TREM2 modulation but couldn't define when to switch from inhibition to activation. The Skeptic noted AD lacks discrete temporal phases, making this critical for any temporal therapeutic strategy.
Source: Debate session sess_SDA-2026-04-10-trem2-ad (Analysis: trem2-ad)