🔬 Analysis Details
Does TFEB activation directly restore mutant GBA enzyme activity or only enhance lysosomal biogenesis?
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molecular biology
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The debate identified this as a critical mechanistic gap - TFEB may increase lysosomal volume without addressing the fundamental GBA enzyme defect. This distinction is essential for determining therapeutic efficacy and predicting which GBA mutations would respond.
Source: Debate session sess_SDA-2026-04-10-gba-pd (Analysis: gba-pd)