🔬 Analysis Details
Can pathological vs physiological C1q tagging be distinguished at the molecular level?
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neurodegeneration
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The debate revealed a fundamental gap: whether disease-specific C1q conformational changes or co-localization patterns exist that could enable selective therapeutic targeting. This selectivity problem was identified as 'unsolvable with current technology' but remains critical for complement-based therapies.
Source: Debate session sess_sda-2026-04-01-gap-v2-691b42f1 (Analysis: sda-2026-04-01-gap-v2-691b42f1)