🔬 Analysis Details
Can TREM2 receptor switching from agonism to antagonism be achieved safely without tolerance or rebound inflammation?
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neurodegeneration
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The stage-dependent strategy assumes sequential drug switching is feasible, but no evidence exists for safe receptor modulation reversal. The skeptic raised concerns about desensitization and rebound effects that could cause harmful neuroinflammation.
Source: Debate session sess_SDA-2026-04-06-gap-001 (Analysis: SDA-2026-04-06-gap-001)