🔬 Analysis Details
How can CRISPR systems achieve persistent therapeutic effects while avoiding chronic immune responses to Cas proteins in the CNS?
archived
gene therapy
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The debate highlighted that long-term CRISPR expression triggers immune responses, but epigenetic therapies require persistence. No clear solution exists for balancing therapeutic duration with immunogenicity in brain tissue.
Source: Debate session sess_SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 (Analysis: SDA-2026-04-02-gap-crispr-neurodegeneration-20260402)