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What are the molecular signatures that distinguish protective vs. harmful microglial states across AD, PD, and ALS?
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neurodegeneration
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The debate transcript shows incomplete information exchange, suggesting this fundamental question about microglial phenotyping remains unresolved. Without clear molecular markers, therapeutic strategies to shift microglia toward protective states cannot be rationally designed or monitored.
Source: Debate session sess_SDA-2026-04-02-gap-microglial-subtypes-20260402004119 (Analysis: SDA-2026-04-02-gap-microglial-subtypes-20260402004119)