🔬 Analysis Details
Can biased TREM2 agonists selectively activate DAP12-SYK-PI3K without triggering ERK-AP1 inflammatory pathways?
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molecular biology
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The theorist proposed this novel approach to enable safe agonism across disease stages, but no evidence exists for such selective pathway activation. This represents a critical gap for developing safer TREM2 therapeutics.
Source: Debate session sess_SDA-2026-04-01-gap-001 (Analysis: SDA-2026-04-01-gap-001)