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What is the actual quantitative contribution of FcRn-mediated transcytosis to BBB antibody transport in humans?
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neuropharmacology
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The debate revealed conflicting estimates ranging from <5% to 20% for FcRn's role in BBB transport, with species differences unresolved. This fundamental uncertainty undermines rational design of FcRn-targeted therapeutics and dosing strategies.
Source: Debate session sess_SDA-2026-04-01-gap-008 (Analysis: SDA-2026-04-01-gap-008)