🔬 Analysis Details
Does DNAJB6 directly inhibit cross-seeding between tau, α-synuclein, and TDP-43 or only homologous aggregation?
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neurodegeneration
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The debate revealed that DNAJB6 evidence is limited to polyglutamine aggregation, with no direct testing of heterologous cross-seeding inhibition. This fundamental gap undermines the universal inhibitor hypothesis and requires specific cross-seeding assays.
Source: Debate session sess_SDA-2026-04-01-gap-9137255b (Analysis: SDA-2026-04-01-gap-9137255b)