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Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD pathogenesis?
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neurodegeneration
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The abstract suggests that Aβ-tau synergy could explain negative results from anti-Aβ trials, contradicting the expectation that targeting the presumed initiating pathology would be therapeutic. This contradiction has major implications for therapeutic strategy design.
Gap type: contradiction
Source paper: Synergy between amyloid-β and tau in Alzheimer's disease. (2020, Nature neuroscience, PMID:32778792)