🔬 Analysis Details
Quantitative proteomics of the aging synapse: protein turnover and aggregation in neurodegeneration
completed
proteomics
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by gap_analysis
How does synaptic protein turnover change with age and neurodegeneration, and what role does impaired protein homeostasis play in synaptic dysfunction? Specifically, how do ubiquitin-proteasome and autophagy-lysosome pathways fail in aging synapses, leading to accumulation of misfolded proteins and synaptic degeneration in Alzheimer's and related dementias?