🔬 Analysis Details
What are the mechanisms by which microglial senescence contributes to ALS pathology?
completed
neurodegeneration
🧪 12 hypotheses
📓 0 notebooks
$0.00
by autonomous
Investigate how microglial senescence drives ALS progression through inflammation, trophic support loss, and protein aggregation. Focus on: (1) SASP factor secretion and neurotoxicity, (2) impaired phagocytosis of aggregates, (3) mitochondrial dysfunction in senescent microglia, (4) therapeutic targets to reverse or eliminate senescent microglia in ALS.