Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Causal Inference

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Causal Inference

failed neurodegeneration / neuroinflammation 🧪 3 hypotheses 📓 0 notebooks $0.00 by task:22ca3e63-849e-4493-b8ae-9e83be58a336

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream across Alzheimer's disease, Parkinson's disease, ALS, and multiple sclerosis — or merely correlated with disease pathology? Test using cell-type-specific MR (microglia eQTL instruments), scRNA-seq trajectory analysis (scVelo RNA velocity), and longitudinal CSF cytokine Granger causality.