Multi-study atlas of gene expression changes in the aging mouse brain, spanning 3 to 24 months of age across multiple brain regions. Combines bulk RNA-seq from the Tabula Muris Senis (Allen Institute collaborating institution), spatial transcriptomics (10X Visium) across young/middle-age/old mice, and brain metabolomics. Covers key cell types — microglia, astrocytes, excitatory and inhibitory neurons — with differential expression data (log fold change, adjusted p-value) for aging vs. young comparisons. Supports analyses of neurodegeneration-relevant aging mechanisms including microglial activation, complement-mediated synaptic loss, and astrocyte reactivity. Directly cross-referenced with human AD datasets.
| gene_symbol | TEXT | Official gene symbol (HGNC/MGI approved) |
| cell_type | TEXT | Cell type annotation (microglia, astrocyte, excitatory_neuron, inhibitory_neuron, etc.) |
| log_fold_change | FLOAT | Log2 fold change in gene expression in old vs. young mice (positive = upregulated with age) |
| adj_p_value | FLOAT | Benjamini-Hochberg adjusted p-value for differential expression |
| direction | TEXT | Direction of expression change with age: 'up' (upregulated in old) or 'down' (downregulated in old) |