🔬 Analysis Details
Human connectome alterations and network-level dysfunction in Alzheimer disease
completed
neurodegeneration / connectomics
🧪 1 hypotheses
📓 0 notebooks
$0.01
by gap_analysis
How do structural and functional connectivity changes in the human brain connectome drive cognitive decline in Alzheimer disease? Investigate: (1) default mode network disruption and amyloid deposition patterns, (2) hippocampal-cortical memory circuit disconnection, (3) white matter tract degeneration measured by diffusion tensor imaging, (4) functional hyperconnectivity as compensatory mechanism vs early pathology marker, (5) sleep-wake cycle disruption and thalamic connectivity changes, (6) sa