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What are the optimal timing windows for TREM2 agonism vs antagonism across disease progression stages?
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neurodegeneration
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The debate highlighted that TREM2 therapeutic targeting remains contested across disease stages, but no clear framework exists for when to activate versus inhibit TREM2 signaling. This timing question is critical for clinical translation but remains empirically unresolved.
Source: Debate session sess_SDA-2026-04-02-gap-001 (Analysis: SDA-2026-04-02-gap-001)