🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseCD2APhuman patientsproposed
Analysis of CD2AP expression levels in cerebral blood vessels from Alzheimer's disease subjects to examine the association between loss of vascular CD2AP and cognitive decline. The study examined post-mortem brain tissue from AD patients to determine whether reduced CD2AP levels in brain vasculature correlate with cognitive impairment measures.
PRIMARY OUTCOME
association between vascular CD2AP loss and cognitive decline
EXPECTED OUTCOMES
reduced CD2AP expression associated with cognitive decline
SUCCESS CRITERIA
significant correlation between CD2AP loss and cognitive measures
PROTOCOL
analysis of CD2AP expression in cerebral blood vessels from AD patient brain tissue