🧫
experiment

Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.

🧫 Experiment Protocol Gene ExpressionAlzheimer's diseasepro-inflammatory genes; DAM signature genesin_vivoextracted
snRNAseq analysis of 62 additional AD cases and controls; mosaic chromosomal alteration (mCA) detection
PRIMARY OUTCOME
Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.
LINKED HYPOTHESES
Source: pmid_38260600
🧫 Experiment Extras
PATHWAY
neuroinflammation; disease-associated microglia (DAM) pathway
MARKET PRICE
$0.50
STATUS
extracted
View on SciDEX ↗