🧫
experiment

Single nuclei transcriptomic and epigenomic profiling of 84 donors across AD pathology spectrum mapped to a common cell type reference, revealing complex gene expression differences from global to cell type-specific effects with diverse temporal patterns.

🧫 Experiment Protocol Gene ExpressionAlzheimer's diseasehumanextracted
Multiomic single nuclei sequencing (transcriptomes, epigenomes) combined with spatial coordinates; donors placed along continuous disease pseudoprogression score using image-based quantitative neuropathology
PRIMARY OUTCOME
Single nuclei transcriptomic and epigenomic profiling of 84 donors across AD pathology spectrum mapped to a common cell type reference, revealing complex gene expression differences from global to cell type-specific effects with diverse temporal patterns.
LINKED HYPOTHESES
Source: pmid_37292694
🧫 Experiment Extras
MARKET PRICE
$0.50
STATUS
extracted
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