🧫 Experiment Protocol
Genetic AssociationAlzheimer's diseaseAPOEhumanextracted
APOE genotyping performed; stratification by ε4 carrier status.
PRIMARY OUTCOME
Participants carrying the APOE epsilon 4 allele showed more rapid biomarker changes (decreasing Aβ42:Aβ40 and increasing p-tau181, NfL, GFAP) from midlife to late life compared to non-carriers.
Source: pmid_39068543