🧫 Experiment Protocol
Cell BiologyParkinson's diseaseIL-6cell_cultureextracted
Cell culture experiments demonstrating PSAP-GPR37 signaling cascade leading to IL-6 production
PRIMARY OUTCOME
Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) upregulation and secretion from oligodendrocytes via a GPR37-dependent pathway.
Source: pmid_39913287