🧫 Experiment Protocol
Animal ModelParkinson's diseaseANXA1mouseextracted
Functional experiment using genetic/inhibition approach; demonstrates sufficiency of Anxa1+ DANs for motor symptoms
PRIMARY OUTCOME
Inhibition of transmitter release specifically in Anxa1+ neurons was sufficient to induce bradykinesia and tremor, demonstrating this vulnerable subtype drives early motor symptoms.
Source: pmid_39763754