Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory an

🧫 Experiment Protocol ComputationalAlzheimer's diseasehumanextracted

Multiomics and spatial genomics using BRAIN Initiative reference atlases; donors placed on disease pseudoprogression score using quantitative neuropathology; replication in other major AD studies

PRIMARY OUTCOME

Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.

LINKED HYPOTHESES

h-44b1c9d415 · TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease

Source: pmid_39402379