🧫
experiment

Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.

🧫 Experiment Protocol Genetic AssociationAlzheimer's diseasecancer driver genes; CSF1R; clonal hematopoiesis genesin_vivoextracted
Molecular-barcoded deep sequencing (>1000X coverage); analysis of sSNVs and sIndels in cancer driver genes
PRIMARY OUTCOME
Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.
LINKED HYPOTHESES
Source: pmid_38260600
🧫 Experiment Extras
PATHWAY
clonal hematopoiesis; microglial clonal expansion (MiCE)
MARKET PRICE
$0.50
STATUS
extracted
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