Longitudinal plasma biomarker study measuring Aβ42:Aβ40 ratio, p-tau181, NfL, and GFAP at midlife and late life in 1525 ARIC participants found that decreasing Aβ42:Aβ40 and increasing p-tau181, NfL, and GFAP over time were associated with incident all-cause dementia, with the strongest late-life as

🧫 Experiment Protocol ClinicalAlzheimer's diseaseAPOEhumanextracted

Plasma biomarkers measured using Quanterix Simoa platform; incident dementia ascertained from neuropsychological assessments, participant contact, and medical record surveillance from 2012-2019.

PRIMARY OUTCOME

Longitudinal plasma biomarker study measuring Aβ42:Aβ40 ratio, p-tau181, NfL, and GFAP at midlife and late life in 1525 ARIC participants found that decreasing Aβ42:Aβ40 and increasing p-tau181, NfL, and GFAP over time were associated with incident all-cause dementia, with the strongest late-life association for NfL (HR 1.92).

LINKED HYPOTHESES

h-immunity-c64967ab · TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM

Source: pmid_39068543