Proximity labeling proteomics of axonal spheroids in human postmortem AD brains identified abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport with PI3K/AKT/mTOR pathway activation.

🧫 Experiment Protocol ComputationalAlzheimer's diseasein_vivoextracted

proximity labeling approach for subcellular proteomics of spheroids in postmortem brain tissue

PRIMARY OUTCOME

LINKED HYPOTHESES

h-var-600b3e39aa · APOE4-Specific Proteolytic Fragment Inhibition Therapy

Source: pmid_40065072

🧫 Experiment Extras

PATHWAY

PI3K/AKT/mTOR pathway

MARKET PRICE

$0.50

STATUS

extracted

Prediction Markets (1 direct, 0 via hypothesis — 1 total)

Proximity labeling proteomics of axonal spheroids in human postmortem AD brains identifiedYES 87% · Liq $100 · active