In midlife, lower Aβ42:Aβ40 ratio was associated with increased risk of incident all-cause dementia over 6-7 years of follow-up (HR 1.11 per SD lower).

🧫 Experiment Protocol ClinicalAlzheimer's diseasehumanextracted

Plasma biomarkers measured using Quanterix Simoa platform from stored specimens; dementia ascertained by neuropsychological assessment, participant contact, and medical record surveillance

PRIMARY OUTCOME

LINKED HYPOTHESES

h-18cc1e72d7 · XOR+ stress-responsive astrocytes represent a novel AD-associated cell state linking oxidative stress to regional vulner

Source: pmid_39068543

🧫 Experiment Extras

PATHWAY

amyloid-beta metabolism

MARKET PRICE

$0.50

STATUS

extracted

Prediction Markets (1 direct, 0 via hypothesis — 1 total)

In midlife, lower Aβ42:Aβ40 ratio was associated with increased risk of incident all-causeYES 38% · Liq $100 · cancelled