🧫 Experiment Protocol
ClinicalAlzheimer's diseaseAPOEhumanextracted
APOE genotyping performed; longitudinal biomarker changes compared between ε4 carriers and non-carriers
PRIMARY OUTCOME
APOEε4 carriers showed more rapid biomarker changes (decreasing Aβ42:Aβ40, increasing p-tau181, NfL, and GFAP) from midlife to late life compared to non-carriers.
Source: pmid_39068543