🧫 Experiment Protocol
Animal ModelParkinson's diseasemouseextracted
MitoPark mice model mitochondrial dysfunction in DANs; time course of Anxa1+ neuronal loss compared to motor symptom onset
PRIMARY OUTCOME
MitoPark mice were used to model PD progression, showing that Anxa1+ dopaminergic neurons are selectively lost earlier than other neuronal subtypes, with degeneration aligning with motor symptom development.
Source: pmid_39763754