🧫
experiment

Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.

🧫 Experiment Protocol Genetic AssociationAlzheimer's diseasecancer driver genes; clonal hematopoiesis genes (CSF1R)in_vivoextracted
Three orthogonal methods used across three independent AD cohorts; bulk RNA sequencing approach for variant detection
PRIMARY OUTCOME
Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.
LINKED HYPOTHESES
Source: pmid_38260600
🧫 Experiment Extras
PATHWAY
somatic mutation accumulation; clonal hematopoiesis
MARKET PRICE
$0.50
STATUS
extracted
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