Integrated multiomics and spatial genomics analysis of 84 human donors revealed two distinct disease phases: an early phase with inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and oligodendrocyte precursor cell remyelination; and a later phase with exponential

🧫 Experiment Protocol NeuropathologyAlzheimer's diseasehumanextracted

Quantitative neuropathology used to assign donors along disease pseudoprogression score; findings replicated in other major AD studies; BRAIN Initiative reference atlases integrated

PRIMARY OUTCOME

Integrated multiomics and spatial genomics analysis of 84 human donors revealed two distinct disease phases: an early phase with inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and oligodendrocyte precursor cell remyelination; and a later phase with exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.

LINKED HYPOTHESES

h-aging-h1-neuroinflam · Age-related neuroinflammation mimics early Alzheimer's disease pathology

Source: pmid_39402379