🧫 Experiment Protocol
ClinicalAlzheimer's diseasehumanextracted
Midlife risk factors (hypertension, diabetes, lipids, coronary heart disease, cigarette use, physical activity) assessed in 1993-1995.
PRIMARY OUTCOME
Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increases, suggesting modifiable risk factors influence biomarker trajectories.
Source: pmid_39068543