Proximity labeling proteomics of axonal spheroids in mouse AD model brains identified abnormalities in protein turnover, cytoskeleton dynamics, and lipid transport with PI3K/AKT/mTOR pathway activation.

🧫 Experiment Protocol ComputationalAlzheimer's diseasein_vivoextracted

proximity labeling approach for subcellular proteomics of spheroids in mouse brain

PRIMARY OUTCOME

LINKED HYPOTHESES

h-var-600b3e39aa · APOE4-Specific Proteolytic Fragment Inhibition Therapy

Source: pmid_40065072