🧫 Experiment Protocol
Gene Expressionproposed
SUMMARY
Single-nucleus RNA sequencing of temporal neocortex showed nominally increased mosaic chromosomal alterations associated with clonal hematopoiesis; microglia carrying mCA exhibited upregulated pro-inflammatory genes resembling disease-associated microglia (DAM) signature.
METHODOLOGY NOTES
snRNAseq analysis of 62 additional AD cases and controls; mosaic chromosomal alteration (mCA) detection
N = {'case': None, 'total': 62, 'units': 'subjects', 'control': None}tissue: temporal neocortexspecies: homo_sapiens