🧫 Experiment Protocol
Computationalproposed
SUMMARY
Single-cell/multiomics analysis of 84 human post-mortem brains revealed two AD disease phases: early phase characterized by inflammatory microglia, reactive astrocytes, loss of SST+ inhibitory neurons and OPC remyelination; later phase showing exponential pathology increase and loss of excitatory and Pvalb+/Vip+ inhibitory neurons.
METHODOLOGY NOTES
Multiomics and spatial genomics using BRAIN Initiative reference atlases; donors placed on disease pseudoprogression score using quantitative neuropathology; replication in other major AD studies
N = {'case': None, 'total': 84, 'units': 'subjects', 'control': None}tissue: middle temporal gyrusspecies: homo_sapiens