🧫 Experiment Protocol
Genetic Associationproposed
SUMMARY
Molecular-barcoded deep (>1000X) gene panel sequencing showed enrichment of sSNVs and sIndels in cancer driver genes in AD brain, with recurrent mutations in clonal hematopoiesis genes and up to 40% of microglia carrying pathogenic sSNVs.
METHODOLOGY NOTES
Molecular-barcoded deep sequencing (>1000X coverage); analysis of sSNVs and sIndels in cancer driver genes
N = {'case': None, 'total': 311, 'units': 'samples', 'control': None}tissue: prefrontal cortexspecies: homo_sapiens