🧫 Experiment Protocol
Animal Modelproposed
SUMMARY
MitoPark mice were used to model PD progression, showing that Anxa1+ dopaminergic neurons are selectively lost earlier than other neuronal subtypes, with degeneration aligning with motor symptom development.
METHODOLOGY NOTES
MitoPark mice model mitochondrial dysfunction in DANs; time course of Anxa1+ neuronal loss compared to motor symptom onset
tissue: ventral substantia nigra pars compactaspecies: mus_musculus