🧫 Experiment Protocol
Genetic Associationproposed
SUMMARY
Bulk RNA sequencing of 866 brain samples revealed significantly higher (~two-fold) overall burden of somatic single-nucleotide variants in AD brains compared to age-matched controls.
METHODOLOGY NOTES
Three orthogonal methods used across three independent AD cohorts; bulk RNA sequencing approach for variant detection
N = {'case': None, 'total': 866, 'units': 'samples', 'control': None}tissue: multiple brain regions (prefrontal cortex, temporal neocortex)species: homo_sapiens