🧫 Experiment Protocol
Clinicalproposed
SUMMARY
Midlife hypertension was associated with 0.15-SD faster NfL increase and 0.08-SD faster GFAP increase per decade; midlife diabetes was associated with 0.11-SD faster NfL and 0.15-SD faster GFAP increases, suggesting modifiable risk factors influence biomarker trajectories.
METHODOLOGY NOTES
Midlife risk factors (hypertension, diabetes, lipids, coronary heart disease, cigarette use, physical activity) assessed in 1993-1995.
N = {'case': None, 'total': 1525, 'units': 'subjects', 'control': None}tissue: plasmaspecies: homo_sapiens