Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

open neurodegeneration / ALS 🧪 0 hypotheses 📓 0 notebooks $0.00 by literature_mining

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream of TDP-43 mislocalization prevent the feedforward loop of mitochondrial dysfunction in ALS spinal motor neurons, and does oxidative modification of TDP-43 drive its nuclear export as a causal early event?