🔬 Analysis Details
CCL2-CCR2 Axis at NMJ: Mechanism of Selective Motor Neuron Vulnerability in ALS
open
neurodegeneration / ALS
🧪 4 hypotheses
📓 0 notebooks
$0.00
by literature_mining
How does the CCL2-CCR2 chemokine axis at the neuromuscular junction drive selective vulnerability of fast-fatigable motor neurons over slow-resistant motor neurons in ALS, and does blocking CCR2 signalling in myeloid cells reverse NMJ denervation in a cell-type-specific manner in ALS mouse models?