No linked papers recorded for this hypothesis yet.
No clinical trials data linked to this hypothesis yet.
No curated ClinVar variants loaded for this hypothesis.
Run scripts/backfill_clinvar_variants.py to fetch P/LP/VUS variants.
No DepMap CRISPR Chronos data found for this gene.
Run python3 scripts/backfill_hypothesis_depmap.py to populate.
No resource usage or linked notebooks recorded for this hypothesis yet.
| Prediction | Predicted | Observed | Status | Conf |
|---|---|---|---|---|
| IF the candidate gene is overexpressed in HeLa cells (transfection with 1 µg plasmid DNA), THEN the cell proliferation rate will increase by at least 40 % relative to empty‑vector controls as measured | ≥40 % increase in MTT signal (indicating enhanced proliferation) at 48 h post‑transfection. | — no observation — | pending | 0.30 |
| IF the candidate gene is silenced using a specific siRNA (50 nM) in iPSC‑derived cortical neurons, THEN the frequency of spontaneous action potentials will decrease by at least 30 % compared with non‑ | ≥30 % reduction in spontaneous action‑potential firing frequency at 24 h after siRNA treatment. | — no observation — | pending | 0.30 |