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figure
Pathway diagram for APOE4
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File not found on disk
46 nodes, 47 edges
DA-2026-04-02-gap-apoe4-targeting/pathway_APOE4_c2db2e2b.svg
Related Entities
APOE4
amyloid beta deposits
dense-core plaques
cerebral amyloid angiopathy
neural connectivity pathways
microRNAs
cognition
amyloid pathology
endothelial integrity
glaucoma
lipid droplets
endolysosomal trafficking
mitochondrial metabolism
innate immune pathways
amyloid-β
tau
neuroinflammation
lipid transport
glucose metabolism
cerebrovascular function
TARDBP
JUN
APOE
ABCA1
sex
brain lipid composition
cognitive decline
TREM2
CGAS
NMDA receptor
apoER2
dimerization
amyloid β-peptide
APP
LGALS3
INPP5D
energy metabolism
neurite damage
cholesterol transport
NFL
triglyceride transport
TLR4/NF-κB pathway
MMP9
LXRβ/ABCA1 pathway
cholesterol efflux
oxidized unsaturated lipids
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